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Restrictions to the Adaptation of Influenza A Virus H5 Hemagglutinin to the Human Host

The binding specificities of a panel of avian influenza virus subtype H5 hemagglutinin (HA) proteins bearing mutations at key residues in the receptor binding site were investigated. The results demonstrate that two simultaneous mutations in the receptor binding site resulted in H5 HA binding in a p...

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Main Authors: Harvey, Ruth, Martin, Andrew C. R., Zambon, Maria, Barclay, Wendy S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC303389/
https://ncbi.nlm.nih.gov/pubmed/14671130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.1.502-507.2004
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