The Oxidized Deoxynucleoside Triphosphate Pool Is a Significant Contributor to Genetic Instability in Mismatch Repair-Deficient Cells

Oxidation is a common form of DNA damage to which purines are particularly susceptible. We previously reported that oxidized dGTP is potentially an important source of DNA 8-oxodGMP in mammalian cells and that the incorporated lesions are removed by DNA mismatch repair (MMR). MMR deficiency is assoc...

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Detalhes bibliográficos
Main Authors: Russo, Maria Teresa, Blasi, Monica Francesca, Chiera, Federica, Fortini, Paola, Degan, Paolo, Macpherson, Peter, Furuichi, Masato, Nakabeppu, Yusaku, Karran, Peter, Aquilina, Gabriele, Bignami, Margherita
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC303369/
https://ncbi.nlm.nih.gov/pubmed/14673178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.1.465-474.2004
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