Nuclear receptor co-repressor SMRT regulates mitochondrial oxidative metabolism and mediates aging related metabolic deterioration

The transcriptional co-repressor SMRT utilizes two major receptor interacting domains (RID1 and RID2) to mediate nuclear receptor (NR) signaling through epigenetic modification. The physiological significance of such interaction remains unclear. We find SMRT expression and its occupancy on peroxisom...

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Autori principali: Reilly, Shannon M., Bhargava, Prerna, Liu, Sihao, Gangl, Matthew R., Gorgun, Cem, Nofsinger, Russell R., Evans, Ronald M., Qi, Lu, Hu, Frank B., Lee, Chih-Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033658/
https://ncbi.nlm.nih.gov/pubmed/21109196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.11.007
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