Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil

Exposure to 6-propyl-2-thio-uracil (PTU), a neonatal goitrogen, leads to increased testis size and sperm production in rodents. Akt1, a gene involved in cell survival and proliferation is also phosphorylated by thyroxine (T(4)). Therefore, we examined the requirement for Akt1 in germ cell survival f...

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Autori principali: Ahmed, Jeena Santos, Brown, Caitlin, Smith, Stuart Duncan, Weston, Paula, Rasoulpour, Teresa, Gilbert, Mary E., Hixon, Mary L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033462/
https://ncbi.nlm.nih.gov/pubmed/20951798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2010.09.012
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