Individual and Cumulative Effects of GWAS Susceptibility Loci in Lung Cancer: Associations after Sub-Phenotyping for COPD

Epidemiological studies show that approximately 20–30% of chronic smokers develop chronic obstructive pulmonary disease (COPD) while 10–15% develop lung cancer. COPD pre-exists lung cancer in 50–90% of cases and has a heritability of 40–77%, much greater than for lung cancer with heritability of 15–...

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Bibliografiske detaljer
Main Authors: Young, Robert P., Hopkins, Raewyn J., Whittington, Chris F., Hay, Bryan A., Epton, Michael J., Gamble, Gregory D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033394/
https://ncbi.nlm.nih.gov/pubmed/21304900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016476
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