Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation

A large number of extracellular polypeptides bound to their cognate receptors activate the transcription factor STAT3 by phosphorylation of tyrosine 705. Supplemental activation occurs when serine 727 is also phosphorylated. STAT3 deletion in mice leads to embryonic lethality. We have produced mice...

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Detalhes bibliográficos
Main Authors: Shen, Yuhong, Schlessinger, Karni, Zhu, Xuejun, Meffre, Eric, Quimby, Fred, Levy, David E., Darnell, J. E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC303338/
https://ncbi.nlm.nih.gov/pubmed/14673173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.1.407-419.2004
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