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Multiplex ligation dependent probe amplification (MLPA) for rapid distinction between unique sequence positive and negative marker chromosomes in prenatal diagnosis

BACKGROUND: Small supernumerary marker chromosomes (sSMC) are extra structurally abnormal chromosomes that cannot be unambiguously identified with conventional chromosome banding techniques. These marker chromosomes may cause an abnormal phenotype or be harmless depending on different factors such a...

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Autori principali: Van Opstal, Diane, Boter, Marjan, Noomen, Petra, Srebniak, Malgorzata, Hamers, Guus, Galjaard, Robert-Jan H
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033356/
https://ncbi.nlm.nih.gov/pubmed/21235775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8166-4-2
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