Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats

BACKGROUND: Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. The chronic neuropathy is a dose-limiting toxicity. We previously reported that repeated administration of oxaliplatin induced cold hyperalgesia in the early p...

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Main Authors: Mihara, Yuki, Egashira, Nobuaki, Sada, Hikaru, Kawashiri, Takehiro, Ushio, Soichiro, Yano, Takahisa, Ikesue, Hiroaki, Oishi, Ryozo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033350/
https://ncbi.nlm.nih.gov/pubmed/21247499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-8
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