Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation

Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. When activated, the NLRP3 (also known as NALP3) inflammasome leads to the production of IL-18 and IL-1β. In this cohort of subjects with knee osteoarthritis (OA), synovial f...

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Detalhes bibliográficos
Main Authors: Denoble, Anna E., Huffman, Kim M., Stabler, Thomas V., Kelly, Susan J., Hershfield, Michael S., McDaniel, Gary E., Coleman, R. Edward, Kraus, Virginia B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033282/
https://ncbi.nlm.nih.gov/pubmed/21245324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012743108
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