PINK1 cleavage at position A103 by the mitochondrial protease PARL

Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a neuroprotective function and is known to localize to mitochondria. Upon entry into the organelle, PINK1 is cleaved to produce a ∼53 kDa pro...

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Bibliographic Details
Main Authors: Deas, Emma, Plun-Favreau, Helene, Gandhi, Sonia, Desmond, Howard, Kjaer, Svend, Loh, Samantha H.Y., Renton, Alan E.M., Harvey, Robert J., Whitworth, Alexander J., Martins, L. Miguel, Abramov, Andrey Y., Wood, Nicholas W.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033179/
https://ncbi.nlm.nih.gov/pubmed/21138942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq526
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