Melanocortin-4-receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

Melanocortin-4-receptor (MC4R) mutations cause dysregulation of energy balance and hyperinsulinemia. We have used mouse models to study the physiological roles of extrahypothalamic MC4Rs. Re-expression of MC4Rs in cholinergic neurons (ChAT-Cre, loxTB MC4R mice) modestly reduced body weight gain with...

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Main Authors: Rossi, Jari, Balthasar, Nina, Olson, David, Scott, Michael, Berglund, Eric, Lee, Charlotte E., Choi, Michelle J., Lauzon, Danielle, Lowell, Bradford B., Elmquist, Joel K.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033043/
https://ncbi.nlm.nih.gov/pubmed/21284986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.01.010
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