Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo

The ‘response to retention’ hypothesis of atherogenesis proposes that proteoglycans bind and retain low-density lipoproteins (LDL) in the vessel wall. Platelet-derived growth factor (PDGF) is strongly implicated in atherosclerosis and stimulates proteoglycan synthesis. Here we investigated the actio...

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Autores principales: Ballinger, Mandy L, Osman, Narin, Hashimura, Kazuhiko, de Haan, Judy B, Jandeleit-Dahm, Karin, Allen, Terri, Tannock, Lisa R, Rutledge, John C, Little, Peter J
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2010
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033015/
https://ncbi.nlm.nih.gov/pubmed/19754668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00902.x
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