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Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans

We present an optogenetic illumination system capable of real-time light delivery with high spatial resolution to specified targets in freely moving Caenorhabditis elegans. A tracking microscope records the motion of an unrestrained worm expressing Channelrhodopsin-2 or Halorhodopsin/NpHR in specifi...

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Main Authors: Leifer, Andrew M, Fang-Yen, Christopher, Gershow, Marc, Alkema, Mark J, Samuel, Aravinthan D T
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032981/
https://ncbi.nlm.nih.gov/pubmed/21240279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1554
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