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Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans

Mirtrons are intronic hairpin substrates of the dicing machinery that generate functional microRNAs. In this study, we describe experimental assays that defined the essential requirements for entry of introns into the mirtron pathway. These data informed a bioinformatic screen that effectively ident...

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Detalhes bibliográficos
Main Authors: Chung, Wei-Jen, Agius, Phaedra, Westholm, Jakub O., Chen, Michael, Okamura, Katsutomo, Robine, Nicolas, Leslie, Christina S., Lai, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032932/
https://ncbi.nlm.nih.gov/pubmed/21177960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.113050.110
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