p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma

We evaluate whether p53-reactivating (p53RA) small molecules induce p53-dependent apoptosis in head and neck squamous cell carcinoma (HNSCC), a question that has not been previously addressed in head and neck cancer. PRIMA-1, CP-31398, RITA, and nutlin-3 were tested in four human HNSCC cell lines di...

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Main Authors: Roh, Jong-Lyel, Kang, Sung Koo, Minn, IL, Califano, Joseph A., Sidransky, David, Koch, Wayne M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032831/
https://ncbi.nlm.nih.gov/pubmed/21109480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2010.10.011
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