CNS-derived CCL21 is both sufficient to drive homeostatic CD4+ T cell proliferation and necessary for efficient CD4+ T cell migration into the CNS parenchyma following Toxoplasma gondii infection

Injury, infection and autoimmune triggers increase CNS expression of the chemokine CCL21. Outside the CNS, CCL21 contributes to chronic inflammatory disease and autoimmunity by three mechanisms: recruitment of lymphocytes into injured or infected tissues, organization of inflammatory infiltrates int...

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Autori principali: Ploix, Corinne C., Noor, Shahani, Crane, Janelle, Masek, Kokoechat, Carter, Whitney, Lo, David D., Wilson, Emma H., Carson, Monica J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032828/
https://ncbi.nlm.nih.gov/pubmed/20868739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2010.09.014
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