Natural variation in life history and aging phenotypes is associated with mitochondrial DNA deletion frequency in Caenorhabditis briggsae

BACKGROUND: Mutations that impair mitochondrial functioning are associated with a variety of metabolic and age-related disorders. A barrier to rigorous tests of the role of mitochondrial dysfunction in aging processes has been the lack of model systems with relevant, naturally occurring mitochondria...

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Main Authors: Estes, Suzanne, Coleman-Hulbert, Anna L, Hicks, Kiley A, de Haan, Gene, Martha, Sarah R, Knapp, Jeremiah B, Smith, Samson W, Stein, Kevin C, Denver, Dee R
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032685/
https://ncbi.nlm.nih.gov/pubmed/21226948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-11-11
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