Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis.

To investigate the pathogenicity of Aspergillus fumigatus mutants lacking putative virulence factors, we have developed a new murine model of invasive pulmonary aspergillosis based on neutropenia, the major factor predisposing patients to this infection. Mice were treated with cyclophosphamide and i...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Smith, J M, Tang, C M, Van Noorden, S, Holden, D W
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303261/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7960101/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.62.12.5247-5254.1994
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