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Synthesis and biological evaluation of new salvinorin A analogues incorporating natural amino acids
The synthesis and in vitro evaluation of a new series of salvinorin A analogues substituted at the C(2) position with natural amino acids is reported. Compound 12, containing Val, displayed high affinity and full agonist activity at the kappa-opioid receptor. Analogues with bulky and/or aromatic res...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031978/ https://ncbi.nlm.nih.gov/pubmed/21115248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.046 |
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