Actively Paranoid Patients with Schizophrenia Over Attribute Anger to Neutral Faces

Previous investigations of the influence of paranoia on facial affect recognition in schizophrenia have been inconclusive as some studies demonstrate better performance for paranoid relative to non-paranoid patients and others show that paranoid patients display greater impairments. These studies ha...

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Main Authors: Pinkham, Amy E., Brensinger, Colleen, Kohler, Christian, Gur, Raquel E., Gur, Ruben C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031724/
https://ncbi.nlm.nih.gov/pubmed/21112186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.schres.2010.11.006
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spelling pubmed-30317242012-02-01 Actively Paranoid Patients with Schizophrenia Over Attribute Anger to Neutral Faces Pinkham, Amy E. Brensinger, Colleen Kohler, Christian Gur, Raquel E. Gur, Ruben C. Schizophr Res Article Previous investigations of the influence of paranoia on facial affect recognition in schizophrenia have been inconclusive as some studies demonstrate better performance for paranoid relative to non-paranoid patients and others show that paranoid patients display greater impairments. These studies have been limited by small sample sizes and inconsistencies in the criteria used to define groups. Here, we utilized an established emotion recognition task and a large sample to examine differential performance in emotion recognition ability between patients who were actively paranoid (AP) and those who were not actively paranoid (NAP). Accuracy and error patterns on the Penn Emotion Recognition test (ER40) were examined in 132 patients (64 NAP and 68 AP). Groups were defined based on the presence of paranoid ideation at the time of testing rather than diagnostic subtype. AP and NAP patients did not differ in overall task accuracy; however, an emotion by group interaction indicated that AP patients were significantly worse than NAP patients at correctly labeling neutral faces. A comparison of error patterns on neutral stimuli revealed that the groups differed only in misattributions of anger expressions, with AP patients being significantly more likely to misidentify a neutral expression as angry. The present findings suggest that paranoia is associated with a tendency to over attribute threat to ambiguous stimuli and also lend support to emerging hypotheses of amygdala hyperactivation as a potential neural mechanism for paranoid ideation. 2010-11-26 2011-02 /pmc/articles/PMC3031724/ /pubmed/21112186 http://dx.doi.org/10.1016/j.schres.2010.11.006 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Pinkham, Amy E.
Brensinger, Colleen
Kohler, Christian
Gur, Raquel E.
Gur, Ruben C.
Actively Paranoid Patients with Schizophrenia Over Attribute Anger to Neutral Faces
description Previous investigations of the influence of paranoia on facial affect recognition in schizophrenia have been inconclusive as some studies demonstrate better performance for paranoid relative to non-paranoid patients and others show that paranoid patients display greater impairments. These studies have been limited by small sample sizes and inconsistencies in the criteria used to define groups. Here, we utilized an established emotion recognition task and a large sample to examine differential performance in emotion recognition ability between patients who were actively paranoid (AP) and those who were not actively paranoid (NAP). Accuracy and error patterns on the Penn Emotion Recognition test (ER40) were examined in 132 patients (64 NAP and 68 AP). Groups were defined based on the presence of paranoid ideation at the time of testing rather than diagnostic subtype. AP and NAP patients did not differ in overall task accuracy; however, an emotion by group interaction indicated that AP patients were significantly worse than NAP patients at correctly labeling neutral faces. A comparison of error patterns on neutral stimuli revealed that the groups differed only in misattributions of anger expressions, with AP patients being significantly more likely to misidentify a neutral expression as angry. The present findings suggest that paranoia is associated with a tendency to over attribute threat to ambiguous stimuli and also lend support to emerging hypotheses of amygdala hyperactivation as a potential neural mechanism for paranoid ideation.
author Pinkham, Amy E.
Brensinger, Colleen
Kohler, Christian
Gur, Raquel E.
Gur, Ruben C.
author_facet Pinkham, Amy E.
Brensinger, Colleen
Kohler, Christian
Gur, Raquel E.
Gur, Ruben C.
author_sort Pinkham, Amy E.
title Actively Paranoid Patients with Schizophrenia Over Attribute Anger to Neutral Faces
title_short Actively Paranoid Patients with Schizophrenia Over Attribute Anger to Neutral Faces
title_full Actively Paranoid Patients with Schizophrenia Over Attribute Anger to Neutral Faces
title_fullStr Actively Paranoid Patients with Schizophrenia Over Attribute Anger to Neutral Faces
title_full_unstemmed Actively Paranoid Patients with Schizophrenia Over Attribute Anger to Neutral Faces
title_sort actively paranoid patients with schizophrenia over attribute anger to neutral faces
publishDate 2010
url https://ncbi.nlm.nih.gov/pmc/articles/PMC3031724/
https://ncbi.nlm.nih.gov/pubmed/21112186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.schres.2010.11.006
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