Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma

We have developed a tumor vaccine in which patient-derived myeloma cells are chemically fused with autologous dendritic cells (DCs) such that a broad spectrum of myeloma-associated antigens are presented in the context of DC-mediated costimulation. We have completed a phase 1 study in which patients...

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Detalhes bibliográficos
Main Authors: Rosenblatt, Jacalyn, Vasir, Baldev, Uhl, Lynne, Blotta, Simona, MacNamara, Claire, Somaiya, Poorvi, Wu, Zekui, Joyce, Robin, Levine, James D., Dombagoda, Dilani, Yuan, Yan Emily, Francoeur, Karen, Fitzgerald, Donna, Richardson, Paul, Weller, Edie, Anderson, Kenneth, Kufe, Donald, Munshi, Nikhil, Avigan, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031474/
https://ncbi.nlm.nih.gov/pubmed/21030562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-277137
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