Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D

We recently reported that Semaphorin 4D (Sema4D) and its receptors are expressed on the platelet surface and showed that Sema4D((−/−)) mice have a selective defect in collagen-induced platelet aggregation and an impaired vascular injury response. Here we investigated the mechanisms involved, tested...

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Hlavní autoři: Wannemacher, Kenneth M., Zhu, Li, Jiang, Hong, Fong, Karen P., Stalker, Timothy J., Lee, Dooyoung, Tran, Anh N., Neeves, Keith B., Maloney, Sean, Kumanogoh, Atsushi, Kikutani, Hitoshi, Hammer, Daniel A., Diamond, Scott L., Brass, Lawrence F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031415/
https://ncbi.nlm.nih.gov/pubmed/20855865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-279943
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