Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and environmental stress. In a screen for conserved substrates of AMPK, we identified ULK1 and ULK2, mammalian orthologs of the yeast protein kinas...

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Autori principali: Egan, Daniel F., Shackelford, David B., Mihaylova, Maria M., Gelino, Sara R., Kohnz, Rebecca A., Mair, William, Vasquez, Debbie S., Joshi, Aashish, Gwinn, Dana M., Taylor, Rebecca, Asara, John M., Fitzpatrick, James, Dillin, Andrew, Viollet, Benoit, Kundu, Mondira, Hansen, Malene, Shaw, Reuben J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030664/
https://ncbi.nlm.nih.gov/pubmed/21205641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1196371
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