Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and environmental stress. In a screen for conserved substrates of AMPK, we identified ULK1 and ULK2, mammalian orthologs of the yeast protein kinas...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Egan, Daniel F., Shackelford, David B., Mihaylova, Maria M., Gelino, Sara R., Kohnz, Rebecca A., Mair, William, Vasquez, Debbie S., Joshi, Aashish, Gwinn, Dana M., Taylor, Rebecca, Asara, John M., Fitzpatrick, James, Dillin, Andrew, Viollet, Benoit, Kundu, Mondira, Hansen, Malene, Shaw, Reuben J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030664/
https://ncbi.nlm.nih.gov/pubmed/21205641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1196371
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