An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations

Mutations in glycyl-, tyrosyl-, and alanyl-tRNA synthetases (GARS, YARS and AARS respectively) cause autosomal dominant Charcot-Marie-Tooth disease, and mutations in Gars cause a similar peripheral neuropathy in mice. Aminoacyl-tRNA synthetases (ARSs) charge amino acids onto their cognate tRNAs duri...

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Hlavní autoři: Stum, Morgane, McLaughlin, Heather M., Kleinbrink, Erica L., Miers, Kathy E., Ackerman, Susan L., Seburn, Kevin L., Antonellis, Anthony, Burgess, Robert W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030653/
https://ncbi.nlm.nih.gov/pubmed/21115117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2010.11.006
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