Antamanide, a Derivative of Amanita phalloides, Is a Novel Inhibitor of the Mitochondrial Permeability Transition Pore

Antamanide is a cyclic decapeptide derived from the fungus Amanita phalloides. Here we show that antamanide inhibits the mitochondrial permeability transition pore, a central effector of cell death induction, by targeting the pore regulator cyclophilin D. Indeed, (i) permeability transition pore inh...

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Autores principales: Azzolin, Luca, Antolini, Nicola, Calderan, Andrea, Ruzza, Paolo, Sciacovelli, Marco, Marin, Oriano, Mammi, Stefano, Bernardi, Paolo, Rasola, Andrea
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030572/
https://ncbi.nlm.nih.gov/pubmed/21297983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016280
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