Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)

Microglial dysfunction is associated with the pathogenesis and progression of a number of neurodegenerative disorders including HIV associated dementia (HAD). HIV promotion of an M1 antigen presenting cell (APC) - like microglial phenotype, through the promotion of CD40 activity, may impair endogeno...

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Main Authors: Salemi, Jon, Obregon, Demian F, Cobb, Anthony, Reed, Spenser, Sadic, Edin, Jin, Jingji, Fernandez, Francisco, Tan, Jun, Giunta, Brian
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Review
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030526/
https://ncbi.nlm.nih.gov/pubmed/21223591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-3
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