The Denatured State Dictates the Topology of Two Proteins with Almost Identical Sequence but Different Native Structure and Function

The protein folding problem is often studied by comparing the mechanisms of proteins sharing the same structure but different sequence. The recent design of the two proteins G(A)88 and G(B)88, displaying different structures and functions while sharing 88% sequence identity (49 out of 56 amino acids...

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Detalhes bibliográficos
Main Authors: Morrone, Angela, McCully, Michelle E., Bryan, Philip N., Brunori, Maurizio, Daggett, Valerie, Gianni, Stefano, Travaglini-Allocatelli, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030387/
https://ncbi.nlm.nih.gov/pubmed/21118804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155911
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