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Control of the specificity of T cell-mediated anti-idiotype immunity by natural regulatory T cells

The idiotypes of B cell lymphomas represent tumor-specific antigens. T cell responses induced by idiotype vaccination in vivo are directed predominantly against CDR peptides, whereas in vitro T cells also recognize framework-derived epitopes. To investigate the mechanisms regulating the specificity...

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Detalhes bibliográficos
Main Authors: Warncke, Max, Buchner, Maike, Thaller, Gudrun, Dodero, Anna, Bulashevska, Alla, Pfeifer, Dietmar, Timmer, Jens, Veelken, Hendrik
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029831/
https://ncbi.nlm.nih.gov/pubmed/20848095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-010-0918-x
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