Natural tri- to hexapeptides self-assemble in water to amyloid β-type fiber aggregates by unexpected α-helical intermediate structures

Many fatal neurodegenerative diseases such as Alzheimer’s, Parkinson, the prion-related diseases, and non-neurodegenerative disorders such as type II diabetes are characterized by abnormal amyloid fiber aggregates, suggesting a common mechanism of pathogenesis. We have discovered that a class of sys...

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Detalhes bibliográficos
Main Authors: Hauser, Charlotte A. E., Deng, Rensheng, Mishra, Archana, Loo, Yihua, Khoe, Ulung, Zhuang, Furen, Cheong, Daniel W., Accardo, Angelo, Sullivan, Michael B., Riekel, Christian, Ying, Jackie Y., Hauser, Ulrich A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029732/
https://ncbi.nlm.nih.gov/pubmed/21205900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014796108
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