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An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors
The La protein binds the 3′ ends of many newly synthesized noncoding RNAs, protecting these RNAs from nucleases and influencing folding, maturation, and ribonucleoprotein assembly. Although 3′ end binding by La involves the N-terminal La domain and adjacent RNA recognition motif (RRM), the mechanism...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3029687/ https://ncbi.nlm.nih.gov/pubmed/21212361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017085108 |
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