Formation of Antiviral Cytoplasmic Granules during Orthopoxvirus Infection

Vaccinia virus (VV) mutants lacking the double-stranded RNA (dsRNA)-binding E3L protein (ΔE3L mutant VV) show restricted replication in most cell types, as dsRNA produced by VV activates protein kinase R (PKR), leading to eIF2α phosphorylation and impaired translation initiation. Here we show that c...

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Main Authors: Simpson-Holley, M., Kedersha, N., Dower, K., Rubins, K. H., Anderson, P., Hensley, L. E., Connor, J. H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2011
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028896/
https://ncbi.nlm.nih.gov/pubmed/21147913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02247-10
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