Characterization of Diverse Subvariants of the Meningococcal Factor H (fH) Binding Protein for Their Ability To Bind fH, To Mediate Serum Resistance, and To Induce Bactericidal Antibodies

Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds human factor H (fH), enabling downregulation of complement activation on the bacterial surface. fHbp is a component of two se...

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Detalhes bibliográficos
Main Authors: Seib, Kate L., Brunelli, Brunella, Brogioni, Barbara, Palumbo, Emmanuelle, Bambini, Stefania, Muzzi, Alessandro, DiMarcello, Federica, Marchi, Sara, van der Ende, Arie, Aricó, Beatrice, Savino, Silvana, Scarselli, Maria, Comanducci, Maurizio, Rappuoli, Rino, Giuliani, Marzia M., Pizza, Mariagrazia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028832/
https://ncbi.nlm.nih.gov/pubmed/21149595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00891-10
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