Biomarker-Assisted Dose Selection for Safety and Efficacy in Early Development of PNU-100480 for Tuberculosis

Tuberculosis is a serious global health threat for which new treatments are urgently needed. This study examined the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple ascending doses of the oxazolidinone PNU-100480 in healthy volunteers, using biomarkers for safety and efficac...

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Detalhes bibliográficos
Main Authors: Wallis, Robert S., Jakubiec, Wesley, Kumar, Vikas, Bedarida, Gabriella, Silvia, Annette, Paige, Darcy, Zhu, Tong, Mitton-Fry, Mark, Ladutko, Lynn, Campbell, Sheldon, Miller, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028776/
https://ncbi.nlm.nih.gov/pubmed/21078950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01179-10
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