Bax Activation by Engagement with, Then Release from, the BH3 Binding Site of Bcl-x(L)

Bcl-2 homologues (such as Bcl-x(L)) promote survival in part through sequestration of “activator” BH3-only proteins (such as Puma), preventing them from directly activating Bax. It is thus assumed that inhibition of interactions between activators and Bcl-x(L) is a prerequisite for small molecules t...

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Main Authors: Gautier, F., Guillemin, Y., Cartron, P. F., Gallenne, T., Cauquil, N., Le Diguarher, T., Casara, P., Vallette, F. M., Manon, S., Hickman, J. A., Geneste, O., Juin, P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028639/
https://ncbi.nlm.nih.gov/pubmed/21173168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00161-10
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