A phase I study of OSI-461 in combination with mitoxantrone in patients with advanced solid tumors potentially responsive to mitoxantrone

PURPOSE: To find the maximum tolerated dose (MTD) of OSI-461 in combination with mitoxantrone in patients with advanced solid tumors. METHODS: This was a Phase I study using cohort dose escalation of OSI-461 dosed orally twice daily in combination with mitoxantrone 12 mg/m(2) given on Day 1 of each...

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Detalhes bibliográficos
Main Authors: Resta, Lee P., Pili, Roberto, Eisenberger, Mario A., Spitz, Avery, King, Serina, Porter, Jennifer, Franke, Amy, Boinpally, Ramesh, Carducci, Michael A., Sweeney, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2010
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028086/
https://ncbi.nlm.nih.gov/pubmed/20445979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1328-7
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