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The cautionary tale of side effects of chronic Notch1 inhibition
Aberrant Notch1 signaling is implicated in several types of cancer. Therefore, Notch signaling pathways are important anticancer targets. Pan–Notch receptor inhibition is associated with numerous complications; thus, selective Notch receptor inhibition has been pursued. Studies have shown minimal si...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3026750/ https://ncbi.nlm.nih.gov/pubmed/21266769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45976 |
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