α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

Post-mortem analyses of brains from patients with Parkinson disease who received fetal mesencephalic transplants show that α-synuclein–containing (α-syn–containing) Lewy bodies gradually appear in grafted neurons. Here, we explored whether intercellular transfer of α-syn from host to graft, followed...

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Detalhes bibliográficos
Main Authors: Hansen, Christian, Angot, Elodie, Bergström, Ann-Louise, Steiner, Jennifer A., Pieri, Laura, Paul, Gesine, Outeiro, Tiago F., Melki, Ronald, Kallunki, Pekka, Fog, Karina, Li, Jia-Yi, Brundin, Patrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026723/
https://ncbi.nlm.nih.gov/pubmed/21245577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43366
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