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Genetic Testing for Long QT Syndrome - Distinguishing Pathogenic Mutations from Benign Variants

BACKGROUND: Genetic testing for long QT syndrome (LQTS) has diagnostic, prognostic, and therapeutic implications. Hundreds of causative mutations in 12 known LQTS-susceptibility genes have been identified. Genetic testing that includes the 3 most commonly mutated genes is available clinically. Disti...

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Detalhes bibliográficos
Main Authors: Kapa, Suraj, Tester, David J., Salisbury, Benjamin A., Harris-Kerr, Carole, Pungliya, Manish S., Alders, Marielle, Wilde, Arthur A. M., Ackerman, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025752/
https://ncbi.nlm.nih.gov/pubmed/19841300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.863076
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