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State reduction for network intervention in probabilistic Boolean networks

Motivation: A key goal of studying biological systems is to design therapeutic intervention strategies. Probabilistic Boolean networks (PBNs) constitute a mathematical model which enables modeling, predicting and intervening in their long-run behavior using Markov chain theory. The long-run dynamics...

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Détails bibliographiques
Auteurs principaux: Qian, Xiaoning, Ghaffari, Noushin, Ivanov, Ivan, Dougherty, Edward R.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025721/
https://ncbi.nlm.nih.gov/pubmed/20956246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btq575
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