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Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

The disintegrin and metalloprotease ADAM12 has important functions in normal physiology as well as in diseases, such as cancer. Little is known about how ADAM12 confers its pro-tumorigenic effect; however, its proteolytic capacity is probably a key component. Thus selective inhibition of ADAM12 acti...

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Bibliografski detalji
Glavni autori: KVEIBORG, Marie, JACOBSEN, Jonas, LEE, Meng-Huee, NAGASE, Hideaki, WEWER, Ulla M., MURPHY, Gillian
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025530/
https://ncbi.nlm.nih.gov/pubmed/20533908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20100649
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