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The Kinetics of Intramolecular Distribution of (15)N in Uric Acid after Administration of [(15)N]Glycine A REAPPRAISAL OF THE SIGNIFICANCE OF PREFERENTIAL LABELING OF N-(3 + 9) OF URIC ACID IN PRIMARY GOUT

The concept of an abnormality of glutamine metabolism in primary gout was first proposed on the basis of isotope data: when [(15)N]glycine was administered to gouty subjects, there was disproportionately great enrichment of N-(3 + 9) of uric acid, which derive from the amide-N of glutamine. An undul...

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Main Authors: Sperling, Oded, Wyngaarden, James B., Starmer, C. Frank
Formato: Artigo
Idioma:Inglês
Publicado em: 1973
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC302506/
https://ncbi.nlm.nih.gov/pubmed/4353999
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