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Long Tract of Untranslated CAG Repeats Is Deleterious in Transgenic Mice

The most frequent trinucleotide repeat found in human disorders is the CAG sequence. Expansion of CAG repeats is mostly found in coding regions and is thought to cause diseases through a protein mechanism. Recently, expanded CAG repeats were shown to induce toxicity at the RNA level in Drosophila an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hsu, Ren-Jun, Hsiao, Kuang-Ming, Lin, Min-Jon, Li, Chui-Yen, Wang, Li-Chun, Chen, Luen-Kui, Pan, Huichin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025035/
https://ncbi.nlm.nih.gov/pubmed/21283659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016417
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