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Survivin-T34A: molecular mechanism and therapeutic potential
The inhibitor of apoptosis protein survivin’s threonine 34 to alanine (T34A) mutation abolishes a phosphorylation site for p34(cdc2)–cyclin B1, resulting in initiation of the mitochondrial apoptotic pathway in cancer cells; however, it has little known direct effects on normal cells. The possibility...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Dove Medical Press
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024888/ https://ncbi.nlm.nih.gov/pubmed/21289859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S15293 |
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