A Cys-loop Mutation in the Caenorhabditis elegans Nicotinic Receptor Subunit UNC-63 Impairs but Does Not Abolish Channel Function

The nematode Caenorhabditis elegans is an established model organism for studying neurobiology. UNC-63 is a C. elegans nicotinic acetylcholine receptor (nAChR) α-subunit. It is an essential component of the levamisole-sensitive muscle nAChR (L-nAChR) and therefore plays an important role in choliner...

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Detalhes bibliográficos
Main Authors: Jones, Andrew K., Rayes, Diego, Al-Diwani, Adam, Maynard, Thomas P. R., Jones, Rachel, Hernando, Guillermina, Buckingham, Steven D., Bouzat, Cecilia, Sattelle, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024750/
https://ncbi.nlm.nih.gov/pubmed/20966081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177238
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