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A Bifunctional Role for Group IIA Secreted Phospholipase A(2) in Human Rheumatoid Fibroblast-like Synoviocyte Arachidonic Acid Metabolism
Human group IIA-secreted phospholipase A(2) (sPLA(2)-IIA) is an important regulator of cytokine-mediated inflammatory responses in both in vitro and in vivo models of rheumatoid arthritis (RA). However, treatment of RA patients with sPLA(2)-IIA inhibitors shows only transient benefit. Using an activ...
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Autors principals: | , , , , , , , , , , , , , , |
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Format: | Artigo |
Idioma: | Inglês |
Publicat: |
American Society for Biochemistry and Molecular Biology
2011
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024744/ https://ncbi.nlm.nih.gov/pubmed/21068383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123927 |
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