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Evolution of molecular error rates and the consequences for evolvability
Making genes into gene products is subject to predictable errors, each with a phenotypic effect that depends on a normally cryptic sequence. Many cryptic sequences have strongly deleterious effects, for example when they cause protein misfolding. Strongly deleterious effects can be avoided globally...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024668/ https://ncbi.nlm.nih.gov/pubmed/21199946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1012918108 |
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