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Theoretical Analysis of the Stress Induced B-Z Transition in Superhelical DNA

We present a method to calculate the propensities of regions within a DNA molecule to transition from B-form to Z-form under negative superhelical stresses. We use statistical mechanics to analyze the competition that occurs among all susceptible Z-forming regions at thermodynamic equilibrium in a s...

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Autors principals: Zhabinskaya, Dina, Benham, Craig J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024258/
https://ncbi.nlm.nih.gov/pubmed/21283778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001051
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