Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice

Huntington's disease (HD) is an inherited neurodegenerative disorder caused by expanded polyglutamine repeats in the huntingtin (Htt) protein. Mutant Htt may damage and kill striatal neurons by a mechanism involving reduced production of brain-derived neurotrophic factor (BDNF) and increased ox...

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Main Authors: Mughal, Mohamed R., Baharani, Akanksha, Chigurupati, Srinivasulu, Son, Tae Gen, Chen, Edmund, Yang, Peter, Okun, Eitan, Arumugam, Thiruma, Chan, Sic L., Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024043/
https://ncbi.nlm.nih.gov/pubmed/21106706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq512
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