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Pharmacological inhibition of intracellular calcium release blocks acid-induced bone resorption
In vivo chronic metabolic acidosis induces net Ca(2+) efflux from bone, and incubation of neonatal mouse calvariae in medium simulating physiological metabolic acidosis induces bone resorption. It appears that activation of the proton (H(+)) receptor OGR1 in the osteoblast leads to an increase in in...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3023220/ https://ncbi.nlm.nih.gov/pubmed/21048027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00276.2010 |
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